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From bench to field: Most advanced TB vaccine in pivotal trials
An eager trial participant in the MVA85A phase IIB infant trial in South Africa. Professor Helen McShane writes from the frontline of efforts to develop the first new TB vaccine in 90 years. The...
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Professor Jane Clarke: How I got into protein research
Illustration of Professor Jane Clarke. Credit: cumi ltd. From the blackboard to the bench: the University of Cambridge’s Professor of Molecular Biophysics, Jane Clarke, started her career as a science...
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Life as a twin-ea pig: Back to the Twin Research Unit
I fell on the four-finger KitKat like a woman possessed. It was nearly 8 hours since my sister and I had eaten. In the meantime, we’d been scanned, weighed, measured and bled. Never had chocolate...
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Q&A: Dr Mayada Elsabbagh on the Autism Research Training Program
Dr Mayada Elsabbagh Interested in the ‘common ground’ bringing together researchers and the communities in which their findings can have an impact, Dr Mayada Elsabbagh from McGill university, Canada,...
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Dance of DNA: A new perspective on genomics
An aerial silk dancer in the performance inspired by ENCODE Attending a press conference at the Science Museum, the journalists, TV cameras and panel of academics were to be expected. But I was not...
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ENCODE decoded for all through open access
ENCODE’s threads “An amazing collaboration,” is how Nature Senior Editor Magdalena Skipper described today’s publication of 30 papers from the ENCODE consortium. Yet Skipper was not referring to the...
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Optimism and pessimism: What makes us who we are?
Some people appear to be incurable pessimists, seeing the negative in everything. Others are upbeat and optimistic convinced they could cope with whatever life throws at them. At the extremes, these...
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Accelerating ageing research
Dr Ilaria Bellantuono of the MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing is one of the founders of ShARM (Shared Ageing Research Models), a new, not-for-profit...
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Mitochondrial diseases: have your say
Three mitochondria surrounded by cytoplasm Last week saw a flurry of headlines after the Human Fertilisation and Embryology Authority (HFEA) launched a public consultation – on behalf of the UK...
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Nasty noises and neuroscience
Chalk on a blackboard? A knife on glass? Even the thought of some of these sounds makes people squirm. In our office the topic sparked an instant discussion, everyone has an opinion as to what sounds...
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TB: When the drugs don’t work
An X-ray showing pulmonary tuberculosis in the left lung (right of picture) Kathryn Lougheed on why tuberculosis is still a problem and the key role of basic research in tackling it. When I tell people...
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Q&A: Cesar Victora – 30 years of Brazil cohort studies
Birth cohort studies follow large numbers of people from birth, collecting information on the health, environmental and socio-economic factors that may affect their long-term health outcomes and human...
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Working out who’s top dog
A new study reveals how the brain interprets information about social hierarchy. Dr Jen Middleton, senior media officer at the Wellcome Trust, explains the findings and what they might mean in real...
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Feature: Keeping time – circadian clocks
Our planet was revolving on its axis, turning night into day every 24 hours, for 4.5 billion years – long before any form of life existed here. About a billion years later, the very first simple...
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Q&A: Dr Anoop Shah on using data from health records
Dr Anoop Shah Information from health records can be extremely useful in medical research, but at the moment not all the data can be extracted automatically. At University College London, Dr Anoop...
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Feature: deceptive appearances – engineering cartilage
An illustration of the changes in articular cartilage that occur in osteoarthritis. Credit: Medical Art Service, Munich, Wellcome Images. The tiny area of uncertainty that is inevitably left by...
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Feature: The biggest poisoning in history
One of the more bitter ironies of human existence is the way the best of our intentions can fall foul of Murphy’s Law and wind up as paving stones on the proverbial road to hell. A recent, devastating...
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Around the world in 80 days – Part 3: Malawi
Scientists in Malawi working with ‘locals’ around 30km from the nearest hospital Over the course of four months, Barry J Gibb visited the Wellcome Trust’s major overseas programmes in Africa and Asia...
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Around the world in 80 days – Part 5: Thailand
Over the course of four months, Barry Gibb visited our major overseas programmes in Africa and Asia to make a film about Wellcome Collection’s Art and Global Health project. In the latest of his diary...
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The digital future of infectious disease maps
The spatial distribution of Plasmodium falciparum malaria endemicity in 2010. You are stuck in bed with a snotty nose and flu. You grab your smart phone and use 140 characters to declare to...
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